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A simple but quick and always amusing prank is putting the screen rotation hotkeys to uses Microsoft never intended. Just run by a co-worker’s desk, reach over and hit Ctrl-Alt-up or down to rotate their monitor orientation. If you have some alone time, you can one-up it by also going into the Control Panel and setting their mouse to left-handed. They’ll spend 10 minutes with their head tilted sideways trying to figure out what the hell is going on.
Have fun
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